Dear NONMEM users,
We all know how difficult it is to simulate full drug trials using NONMEM. It
is often necessary to generate the full dosing scheme(s) beforehand, and
response-based dose adaptation requires iteratively rerunning your model until
you have the results you are happy with.
At S
Dear NONMEM Users Group,
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Actually, nonmem can be used to simulate the response-based dose
adaptation without iteratively rerunning your model, with single
simulation (using $ABB COMRES functionality to pass simulated response
to the dose-adjustment algorithm code), although it is indeed cumbersome
Leonid
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Hi,
In many cases you don't even need to use $ABB COMRES to do response-adaptive
designs, simulated response could just impact a bioavailability term (Fx) of
the next dose(s) to indicate dose change. I'm sure that more complex
response-adaptive designs could benefit from a dedicated software th
Does anyone have an example of using Fn (bioavailability of compartment n) to
do adaptive dosing simulations? I am not having much luck getting it to work.
Mike
Michael J. Fossler, Pharm. D., Ph. D., F.C.P.
VP, Quantitative Sciences
Trevena, Inc
mfoss...@trevenainc.com
Office: 610-354-8840, ext.
This is a very basic code that will reduce bioavailability in half if
some PD effect (the output of the model) drops below 100
$ABB COMRES=1 ; space to save simulated PD
$PK
IF(NEWIND.LT.2) COM(1)=0 ; for each subject, COM(1) starts from zero
F1 = 1
IF(COM(1).EQ.1) F1=0.5 ; if COM(1
Senior Pharmacometrician- Associate Director/Director at Vertex, Boston
Modeling & Simulation methodologies plays an increasingly important role in the
development of new drugs within Vertex Pharmaceuticals and our goal is to fully
implement Model based principles to support drug development pro
