[NMusers] time-to-event simulation based diagnostic

2012-09-19 Thread Francois Gaudreault
Dear NONMEM users I am currently performing a time-to-event analysis on binary data using a weibull distribution (time-varying hazard function). Using simulation based diagnositcs, I compared `simulated kaplan-Meier` to `observed kaplan-Meier`. However, fit looks to good to be true and I was

[NMusers] Clinical Pharmacology positions at Pfizer in Cambridge (MA)

2012-09-19 Thread Nucci, Gianluca
Be influential. Our Clinical Pharmacology Leads have key roles to play in influencing the discovery and development of drugs. It is fascinating, vital work and you could be part of it. Pfizer is a leader in Model Based Drug Development, and we are expanding its influence in target validation

RE: [NMusers] time-to-event simulation based diagnostic

2012-09-19 Thread Mats Karlsson
Dear Francois, Unless you create a new data set where events are allowed to occur at any possible time (usually a dense time grid), then the result that you have got is rather the expected (i.e. too good to be true). Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics