dear NM-community,
Is NONMEM reliably used for single-patient AUC-calculation in cases of
linear PK, or is e.g. WinNonLin (or similar software) preferred in such
cases?
best regards,
Markus
--
Markus Joerger MD PhD
Associate Professor
Medical Oncology&Clinical Pharmacology
Cantonal Hospital
9
Hi Markus,
Typically, AUCs are calculated using software like WinNonlin because it is both
simpler and more objective (the model is simple and specified a priori).
Generally, the model is just used as the linear-up, log-down trapezoidal rule
with personal (or corporate) preferences on handling
Dear Markus,
I guess it depends on how you plan to make the estimation:
1) If it is by NCA, other programs will do this
2) If it is as model-based, non-linear regression, many programs will
do it (incl NONMEM)
3) If you want to analyse the individual data using a previous
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