Hi Ayyappa,
did you try testing it on both volumnws at the same time? Would make more sense
to me.
Regards
Sven
Am 12.08.2012 um 01:20 schrieb Ayyappa Chaturvedula :
> Dear users,
>
> I am finding weight as a covariate on peripheral volume and objective
> function is dropping more than on
Sven,
I tried that and although obj fun reduces by 10 points, theta estimate was very
small for central volume and do not make any big difference with increased
total body weight.
Regards,
Ayyappa
Sent from my iPad
On Aug 12, 2012, at 2:46 AM, "Sven Mensing"
mailto:sv.mens...@gmail.com>> wrote
Hi Ayyappa,
As Sven mentioned, it would make the most sense for it to be a significant
covariate on both central and peripheral volumes.
Just because the objective function value drops more doesn't mean that you
shouldn't include the effect of weight on central volume in your final model.
The
Dear Ayyappa,What about the physicochemical properties of the drug ? Is the
drug lipophilic ?If yes, couldn't this mean that "higher body weight =
increased fat = increased volume in which the drug distributes or dissolves"
?Kind Regards,Ahmed Abbas SuleimanDepartment of Pharmacology - Clinica
Dear Group,
I would like to get your comments on the following:
Intel fortran on Intel and AMD processors:
I would like to install nonmem compiled using Intel fortran compiler
(11.2) in a linux OS with AMD processor. Will the nonmem results of this
installation differ from other processors (n
Martin Yes, the results can be different. Intel has been accused of "crippling" the executable when the Intel compiler is used on AMD CPUshttp://www.agner.org/optimize/blog/read.php?i=49by turning off all optimization - they actually pretty much admitted this in the lawsuit - but explained that i
Hi Martin,
At an arbitrary level of precision, there will likely be differences [1].
These differences are unlikely to affect any model results to a notable degree.
When I've done testing previously with different compilers, processors, and
platforms, changing compilers (gcc vs ifortran) made
Mark,
I think you may not be fully appreciating the terms of the agreement
when you say "it is generally accepted that Intel continues to impair
the optimization on AMD CPU".Under the terms of the agreement (which you
provide below) it is perfectly OK for Intel to optimize their compilers
for
