I am looking for a research assistant to join the project. We are moving on
from structural studies of the enzyme to functional studies (such as PELDOR and
Nanion Surfer). Working with a postdoc in the lab, you will be an integral
member of my team. We are a diverse group of about 15 scientis
Dear Paul,
First and foremost, thanks a lot for your answer.
It is very helpful to get some insight into what's going on with the software,
and you explained it simply and exhaustively.
I will check the overall quality of the model built in Coot that I used as an
input for the last refinement
Dear All,I am working on structures where Methionine is important in binding of
peptides to the MHC protein complex.Would anyone kindly like to share their
knowledge about anything they find it important about this particular amino
acid structurally? Sharing a paper or just few comments will be
Hi Samer,
I came across this interesting article recently, that discusses the
significance of unusually high content of Met in the polymerization
inducing domain of spider silk protein (
https://www.nature.com/articles/s41467-019-12365-5).
Methionines provide a 'mobilization' to the hydrophobic co
Hi Samer,
In addition to what has been already mentioned to you, there are also the
two well illustrated cases of methionine rich domains.
- in the case of the M (for Met rich) domain of the Signal Recognition
Particle protein SRP54/Ffh involved in promiscuous binding of the
N-terminal hydrophobic
Hi Samer,
Adding to Pascal’s list, calmodulin is another protein with many methionines
that provide a flexible binding site. See this review as a starting point for
reading about it: https://pubmed.ncbi.nlm.nih.gov/9923700/.
Best,
Rachelle
__
Dear Sahil,I quickly read part of the paper that you sent. It is very
interesting. Thank you for sharing. Looking forward to read it in details.Best
regards,Samer
On Friday, August 7, 2020, 02:19:20 PM GMT+1, Sahil Batra
wrote:
Hi Samer,
I came across this interesting article recentl
Hello Rachelle,Many thanks for sharing the link and for your kind help. I
could read the abstract only and failed to get the PDF of the full text due to
access issues. Is it possible to kindly send the paper if that is Ok with you?
If there will be any copyright issues, please do not worry abou
Hi Samer,
I solved a pair of structures in which a methionine rich amphipathic
peptide extending from a coiled coil protein formed two different, fairly
intimate crystal contacts in two different crystal forms (see Figure 3). It
seems the methionine rich side of this peptide really wanted to be bu
Hello Jessica,Many thanks for your kind help. I skimmed the paper quickly and
I find it very interesting, looking forward to read it in depth.Thank you
again.Best regards,Samer
On Friday, August 7, 2020, 04:23:23 PM GMT+1, Jessica Bruhn
wrote:
Hi Samer,
I solved a pair of structures i
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