*Postdoctoral position in structural biology of protein complexes in
nerve development and disease*
Dept. of Medical Biochemistry and Biophysics, Karolinska Institute
A postdoctoral position is available immediately in the Molecular
Structural Biology group at the Karolinska Institute in Stock
Job Title
Postdoctoral Research Scientist
Description
Vernalis is a specialist bio-pharmaceutical company with a marketed
product, frovatriptan, several product candidates in clinical trials and
a research capability based on structure-based drug discovery
technologies.
We are seeking a macromolecu
Hi Amit,
I wouldn't worry about acetate depleting the Sm3+. I have tried to
make a derivative of a kinase by soaking ions of lanthanoid series but
in the presence of phosphate buffer and ADP. In this case, lanthanoid
ions are *known* to precipitate with phosphate (and phosphoryl
moiety).
I have a 3.0 A structure which has a Mg liganded by a His NE and a substrate
carboxylate at around 2.1 -2.3 A.
There are a number of other potential liganding amino acid atoms at between 3.2
and 4.5 A. This is clearly
longer than the direct bonding distances found by Harding
http://journals.iuc
Hi Matt,
In addition to the other helpful comments, I have also found that if
you are using reducing agent, this complicates
issues furthers due to metal complexation, I suppose. If you do need
a reducing agent
for your protein, I would suggest adding TCEP instead of BME or DTT,
as this
ha
Dear All,
I am trying to use getax for finding NCS in a map radius of 100A and get
the error 'ERROR: more than MAXPTS points in sphere - please recompile'.
I am running CCP4 6.0.2 on my intel macbook pro. I am not sure which
parameter to change in the getax.f file and how to exactly recompile
Dear Vidya,
On Tue, Apr 07, 2009 at 02:20:42PM +0100, Vidya Chandran wrote:
> Dear All,
>
> I am trying to use getax for finding NCS in a map radius of 100A and get
> the error 'ERROR: more than MAXPTS points in sphere - please recompile'.
I guess you're using a sphere of radius 100A for sear
Hi all I've got a quick question regarding ccp4mg which hopefully isn't
rtfm. I'm making some pictures at the moment and the inner artist in me is
feeling slightly limited by the 17 colours on offer. Is there any way of
adding RGB definitions. I've had a little play with the colours.def and
colo
I've found out how to do it on ccp4mg but I was working with the new QtMG,
still can't find where to do it there though.
Ambrose
This communication is from Cancer Research UK. Our website is at
www.cancerresearchuk.org. We are a charity registered under number 1089464 and
a company limited by
Greetings,
I have a feeling that this is a stupid question. But I am baffled here and
I need some help:
I am working with a solid 3.0 Angstrom native data set. Processed in
HKL2000. I created the mtz file and used a homemade poly-Ala model as a
probe for molecular replacement. Both PHASER and
Hi Nick,
Have you checked the web services provided by Marjorie Harding?
http://tanna.bch.ed.ac.uk/index.html
http://eduliss.bch.ed.ac.uk/MESPEUS/
Maybe, you can also find information about water mediated contacts over
there. The first web site gives also some links to other interesting web
pages
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