Hi Christian
We often use a simple approach where people design their experiments using
rational multivariate design, but then simply use the best well that is found
as the centre of the next round of experiments. This means that you don't have
to score all the wells - which is time-consuming!
Christian,
I happened to see your post to the CCP4 bulletin board. In answer to
your question, we continue to base all of our work on proper
experimental design. Two papers cited below document the flexibility
and power of response surface methods in biochemical experimentation,
especiall
