This discussion seems to have moved a very long way from the original
topic, and hence the reported "Subject", could this be continued as a
new thread please ?
Thanks
Andrew
On 17 Nov 2009, at 11:40, Morten Kjeldgaard wrote:
Tim Gruene wrote:
Yes, but models that can be validated again
Tim Gruene wrote:
Yes, but models that can be validated against experimental data. The
defining characteristics of computational models is that they (A)
are 100% dependent on the algortihm, (B) can't be validated at all.
Cheers,
Morten
>>> Sorry, they can be validated
I would say that any prediction that can be derived from a model and
confirmed is a validation of the model and the model remains valid until
replaced by a better one. The sun was orbiting the earth until evidence
became too contradictorily for this model. Until then it was a good model
- bette
From: CCP4 bulletin board [mailto:ccp...@jiscmail.ac.uk] On Behalf Of
Morten Kjeldgaard
Sent: 17 November 2009 09:56
To: CCP4BB@JISCMAIL.AC.UK
Subject: Re: [ccp4bb] video that explains, very simply, what Structural
Molecular Biology is about
On 17/11/2009, at 08.10, mesters wrote:
>>
On 17/11/2009, at 08.10, mesters wrote:
Yes, but models that can be validated against experimental data.
The defining characteristics of computational models is that they
(A) are 100% dependent on the algortihm, (B) can't be validated at
all.
Cheers,
Morten
Sorry, they can be validated t
Kjeldgaard Morten wrote:
On 14/11/2009, at 20.17, Miguel Ortiz Lombardia wrote:
Le 14 nov. 09 à 19:15, Kjeldgaard Morten a écrit :
On 14/11/2009, at 18.55, Ronald E Stenkamp wrote:
The rumblings here at the Univ. of Washington among the
computational modelers is that some of their current m
e M. Sheldrick
Sent: Sat 11/14/2009 4:08 AM
To: CCP4BB@JISCMAIL.AC.UK
Subject: Re: [ccp4bb] video that explains, very simply, what Structural
Molecular Biology is about
Apologies for the typo, I meant to say 'Bernhard'.
George
Prof. George M. Sheldrick FRS
Dept. Structural Chemistry,
Un
On 15 Nov 2009, at 12:54, Kjeldgaard Morten wrote:
Yes, but models that can be validated against experimental data. The
defining characteristics of computational models is that they (A)
are 100% dependent on the algortihm, (B) can't be validated at all.
Computational models can be validated
Hello everybody-
> Molecular models are the result of numbers emerging from computer programs.
> The results of such computations do not reflect anything in nature. There's
> no experimental evidence whatsoever, making modelling a very theoretical --
> in my eyes uninteresting -- exercise.
Molecu
Le 15 nov. 09 à 12:54, Kjeldgaard Morten a écrit :
On 14/11/2009, at 20.17, Miguel Ortiz Lombardia wrote:
Le 14 nov. 09 à 19:15, Kjeldgaard Morten a écrit :
On 14/11/2009, at 18.55, Ronald E Stenkamp wrote:
The rumblings here at the Univ. of Washington among the
computational modelers is
On 14/11/2009, at 20.17, Miguel Ortiz Lombardia wrote:
Le 14 nov. 09 à 19:15, Kjeldgaard Morten a écrit :
On 14/11/2009, at 18.55, Ronald E Stenkamp wrote:
The rumblings here at the Univ. of Washington among the
computational modelers is that some of their current models might
be more rep
Apologies for the free editing:
> >
> > Molecular models are the result of numbers emerging from computer programs.
> > The results of such computations do not reflect anything in nature. There's
> > no experimental evidence whatsoever, making modelling a very theoretical --
> > in my eyes uninte
:21
> De : "Athanasios Dousis"
> A : CCP4BB@JISCMAIL.AC.UK
> Copie à :
> Objet : Re: [ccp4bb] video that explains, very simply, what Structural
> Molecular Biology is about
>
>
> Fred,
>
> Great video-- thanks for sharing it with us. Could someone (pref
Fred,
Great video-- thanks for sharing it with us. Could someone (preferably
with a personal connection to the French owners) please ask if the
English version can be posted on Google Video or Youtube? I'd like to
distribute the link, but the file is too large for casual downloading
and vie
Le 14 nov. 09 à 19:15, Kjeldgaard Morten a écrit :
On 14/11/2009, at 18.55, Ronald E Stenkamp wrote:
The rumblings here at the Univ. of Washington among the
computational modelers is that some of their current models might
be more representative of protein structures in solution than are
On 14/11/2009, at 18.55, Ronald E Stenkamp wrote:
The rumblings here at the Univ. of Washington among the
computational modelers is that some of their current models might be
more representative of protein structures in solution than are the
crystal structure models. It may take less than
Subject: Re: [ccp4bb] video that explains, very simply, what Structural
Molecular Biology is about
Apologies for the typo, I meant to say 'Bernhard'.
George
Prof. George M. Sheldrick FRS
Dept. Structural Chemistry,
University of Goettingen,
Tammannstr. 4,
D37077 Goettingen, Germany
Tel. +49
ost of the tricks?
Bert van den Berg
UMass Medical School
-Original Message-
From: CCP4 bulletin board on behalf of George M. Sheldrick
Sent: Sat 11/14/2009 4:08 AM
To: CCP4BB@JISCMAIL.AC.UK
Subject: Re: [ccp4bb] video that explains, very simply, what Structural
Molecular Biolog
Le 14 nov. 09 à 10:53, Frederic VELLIEUX a écrit :
Dear Bulletin Board,
The following URL's may help people to understand crystallography
(this was also pointed out to me by Ines Kahlaoui last night, I am
so grateful to her):
http://videolectures.net/mit3091f04_sadoway_lec14/ (for the
B
. Sheldrick"
> A : CCP4BB@JISCMAIL.AC.UK
> Copie à :
> Objet : Re: [ccp4bb] video that explains, very simply, what Structural
> Molecular Biology is about
>
>
> I also think that it is a very nice video and I will certainly be showing
> it to my students (and relatives).
Apologies for the typo, I meant to say 'Bernhard'.
George
Prof. George M. Sheldrick FRS
Dept. Structural Chemistry,
University of Goettingen,
Tammannstr. 4,
D37077 Goettingen, Germany
Tel. +49-551-39-3021 or -3068
Fax. +49-551-39-22582
On Sat, 14 Nov 2009, George M. Sheldrick wrote:
>
> I als
I also think that it is a very nice video and I will certainly be showing
it to my students (and relatives). However the little step between
recording the X-ray reflections and getting a final refined map might be
expanded a little. That is after all what CCP4 etc. is about! Otherwise,
despite t
that explains, very simply, what Structural
Molecular Biology is about
On Nov 11, 2009, at 1:44 AM, Vellieux Frederic wrote:
> but also shows what we crystallographers have known for a long time, since
the first colour E&S graphics workstations in fact, that the electron are
blue
That is th
Rupp"
> A : "'Frederic VELLIEUX'"
> Copie à :
> Objet : RE: [ccp4bb] video that explains, very simply, what Structural
> Molecular Biology is about
>
> I wonder how we could do that best? I used the example of the HIV protease
>
> from his preloaded ex
On Nov 11, 2009, at 1:44 AM, Vellieux Frederic wrote:
> but also shows what we crystallographers have known for a long time, since
> the first colour E&S graphics workstations in fact, that the electron are blue
That is the color of electrons dissolved in liquid ammonia (thus allowing the
viewe
Dear All,
About a year ago I made a short demo video, only intended to illustrate how
robotics
figure in drug target crystallography. It is biased and somewhat out of date
of course, but shows some nice crystal growth, harvesting and data
collection.
Material credits are at the end.
Fo
Just thought this will be of interest to all.
Subbu
--- Begin Message ---
Narayanan Ramasubbu wrote:
Vellieux Frederic wrote:
Narayanan Ramasubbu wrote:
Hi:
Could someone point out the name and where to get these
crystallization plates used in the video?
By the way, this is a wonderful vide
Thank you Dr. Sauter for making such an awesome movie. I am sure it will
be very valuable for teaching as well as for showing the general public
what we do. Definitely try to have the DVD ready for Christmas shopping...
Best regards,
christian
claude sauter wrote:
> Narayanan Ramasubbu a écrit :
The crystallization plates with the screw caps shown 8 minutes into the film
can be purchased from Qiagen (They used to be made by a company called
Nextal but Qiagen bought them out a few years ago). I've been using these
plates for years and love not having to deal with the vacuum grease.
Here i
Narayanan Ramasubbu a écrit :
mb1pja wrote:
Dear Fred
A really nice video that would be great for giving
non-crystallographers (including colleagues and 1st year students, and
perhaps also friends and family) an overview of what we do. Thank you
for pointing it out - and of course very many
Vellieux Frederic wrote:
Hi,
I think the plates are Greiner bio-one plates. We use them on the
nanodrop crystallisation robot at PSB-EMBL (https://htxlab.embl.fr).
Will check with Jean-Luc Ferrer from IBS (if he has not gone home
already, it is late on a Friday...).
Fred.
And the plates wi
Hi,
I think the plates are Greiner bio-one plates. We use them on the
nanodrop crystallisation robot at PSB-EMBL (https://htxlab.embl.fr).
Will check with Jean-Luc Ferrer from IBS (if he has not gone home
already, it is late on a Friday...).
Fred.
Narayanan Ramasubbu wrote:
mb1pja wrote:
mb1pja wrote:
Dear Fred
A really nice video that would be great for giving non-crystallographers
(including colleagues and 1st year students, and perhaps also friends and
family) an overview of what we do. Thank you for pointing it out - and of
course very many thanks to Dominique Sauter for
... and thanks also to Ines Kahlaoui who pointed it out to you!
On 11 Nov 2009, at 09:44, Vellieux Frederic wrote:
> Dear all,
>
> Thought I'd share this with you:
>
> I located this through Ms Ines Kahlaoui, from the Beja Higher Institute of
> Biotechnology in Tunisia (Ines has to teach and
Dear Fred
A really nice video that would be great for giving non-crystallographers
(including colleagues and 1st year students, and perhaps also friends and
family) an overview of what we do. Thank you for pointing it out - and of
course very many thanks to Dominique Sauter for making it. I am
simply, what Structural Molecular Biology is about
> ***
> This message has been scanned by the InterScan for CSC SSM at IICT and found to be free of known security risks.
> ***
>
> Dear all,
>
> Thought I'd share this with you:
&
Dear all,
Thought I'd share this with you:
I located this through Ms Ines Kahlaoui, from the Beja Higher Institute
of Biotechnology in Tunisia (Ines has to teach and locates videos on the
internet, which she then downloads and uses for teaching). Ines located
this jewel:
http://video.google
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