Re: [ccp4bb] Protein fold and the moonlighting function

ot; Sent: Monday, 3 February, 2020 02:18:45 Subject: Re: [ccp4bb] Protein fold and the moonlighting function I think you’re asking if two proteins with the same fold can have different activities. As was previously mentioned, this is quite common. The best characterized example is the TIM barrel fold

Re: [ccp4bb] Protein fold and the moonlighting function

I think you’re asking if two proteins with the same fold can have different activities. As was previously mentioned, this is quite common. The best characterized example is the TIM barrel fold - such proteins can be isomerases, transferases, hydrolases, lyases, or oxidoreductases, to name a fe

Re: [ccp4bb] Protein fold and the moonlighting function

Hello,  Re: "I think you’re asking about 2 proteins with a similar fold having similar but not exactly the same functions - yes, that does occur." Indeed, I suspect it is very common, if not the norm. OK, so I now gather/remember moonlighting proteins are ones with more than one function - than

Re: [ccp4bb] Protein fold and the moonlighting function

Hi Rajnandani, I’m happy to help you with questions about moonlighting proteins. My lab created the MoonProt Database (moonlightingproteins.org). I think you’re asking about 2 proteins with a similar fold having similar but not exactly the same functions - yes

Re: [ccp4bb] Protein fold and the moonlighting function

Can you possibly expand a bit on exactly what you are asking?Jon CooperOn 2 Feb 2020 09:28, Rajnandani Kashyap wrote:Dear AllI am curious to know about the promiscuous activity of a protein based on their fold. Can a protein having same fold also have same function (say not 100% but some activity)

[ccp4bb] Protein fold and the moonlighting function

Dear All I am curious to know about the promiscuous activity of a protein based on their fold. Can a protein having same fold also have same function (say not 100% but some activity) as the homologous structure. Please also let me know few relevant PDB structures where such kind of activity is sh