Hello, Re: "I think you’re asking about 2 proteins with a similar fold having similar but not exactly the same functions - yes, that does occur." Indeed, I suspect it is very common, if not the norm. OK, so I now gather/remember moonlighting proteins are ones with more than one function - thank you for the link to the very interesting database. Is perhaps the questioner asking if homologues of a moonlighting protein also have similar moonlighting functions? If so, I'm out of my depth on that one. Best wishes, Jon Cooper. On Sunday, 2 February 2020, 18:22:10 GMT, Jeffery, Constance J <cjeff...@uic.edu> wrote: Hi Rajnandani, I’m happy to help you with questions about moonlighting proteins. My lab created the MoonProt Database (moonlightingproteins.org). I think you’re asking about 2 proteins with a similar fold having similar but not exactly the same functions - yes, that does occur. Best regards,Connie Jeffery
On Feb 2, 2020, at 4:28 AM, Rajnandani Kashyap <kashyap.rajnand...@gmail.com> wrote: Dear All I am curious to know about the promiscuous activity of a protein based on their fold. Can a protein having same fold also have same function (say not 100% but some activity) as the homologous structure. Please also let me know few relevant PDB structures where such kind of activity is shown promising. Regards Rajnandani Kashyap PhD Student To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
