Dear all,
Registration is now open for our next industry talk on 10 July 2024 at 2pm UK
time. The talk by Steve Maginn, Chemical Computing Group / Molecular Graphics
and Modelling Society, has the title "At the Interface of Academia and Industry
for 35 Years... (aka - "You get less time for m
Many thanks to Mark van Raaij for a super example - 5EFV - clear heterogeneity
at the hinge/kink; although this then doesn't return to the 1st axis
Its interesting to contemplate proteins doing this several times in a
physiologically "real" way (the models I'm looking at do this) - they need gly
The refined crystallographic occupancy (sort of a measure of electron density
quality) has been related to the ligand binding constant. In this study, they
determined several structures of a protein with different concentrations of the
ligand. The binding constant was estimated from a plot of th
(I should note that my use of symmetry is used on the protein level rather on
the absolute crystallographic equivalence level - imagine this trimer sat
within a P1 cell, and that minor wobbles generate pseudosymmetry in places
anyway - what I'm interested in is the topology of the chain at the j
Dear all,
Is there any study that analyzes the relationship between the quality of the
electron density of a ligand and its affinity?
Armando
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Dear wise list,
I have a question regarding protein oligomers that have multiple, differing
axes of symmetry - stimulated by some perplexing but likely real Alphafold
models.
I think it's the protein equivalent of this old chestnut:
https://en.wikipedia.org/wiki/Three_utilities_problem
Consid
