Many thanks to Mark van Raaij for a super example - 5EFV - clear heterogeneity at the hinge/kink; although this then doesn't return to the 1st axis
Its interesting to contemplate proteins doing this several times in a physiologically "real" way (the models I'm looking at do this) - they need gly rich regions, much like the "crossover" in the above example. If you have a trimeric fibre with trimeric lobes on the side, evolution has two choices: 1. Keep all chains on a common axis, make the fibre from 3 chains and the lobes from 3 sequential repeats on the same chain 2. Make all three chains make the fibre and the lobes, each contributing a third to any structural element The question I posed is to do with models that clearly use choice 2...which is toplogically difficult - do they "choose" this to avoid sequence repeats in a protein? Happy to hear more examples if you have them! Thanks Andy ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
