Dear Crystallographic community
there is still time to apply for our latest PhD position on the development of
new algorithms and molecules for PROTACS drugs. This is a fully-funded 4-year
PhD at Durham University together with the Cambridge Crystallographic Data
Center (CCDC) as part of our EP
Dear community,
Electron Bio-Imaging Centre at Diamond Light Source Ltd has a postdoctoral
position available for development of novel concepts and software tools for
cryo-Electron Microscopy data analysis. If you have a PhD or equivalent in
mathematics, computational sciences, physics, biophys
Yes - our CASP15 target H1157 contained intramolecular and
inter-molecular SS bonds - the former were well predicted but the latter
were not:
https://predictioncenter.org/casp15/multimer_results.cgi?target=H1157
The article discussing this aspect (as well a few other CASP15 targets)
is at the
This is very much anecdotal - in my experience, AF2 tends to put the Cys
residues in the disulfide bridge adjacent to each other, sometimes with roughly
the correct side chain orientation.
It doesn't build/refine the S-S bond, becuase I don't think it knows how to.
Best,
Dave
Dr David C. Br
Interesting. Has someone similarly looked at whether AlphaFold predicts
disulfide bridges?
Guillaume
On 13 Jul 2023, at 15:12, Randy John Read
mailto:rj...@cam.ac.uk>> wrote:
I’m not sure about other methods, but AlphaFold does predict peptides in both
cis and trans configurations. In a rece
I’m not sure about other methods, but AlphaFold does predict peptides in both
cis and trans configurations. In a recent paper, Osnat Herzberg and John Moult
show that it was pretty successful in predicting proline cis-peptides, among
the novel structures in the CASP15 set of targets
(https://ww
Does anybody know if cis-peptides are predicted by the AI tools
(AlphaFold2, ColabFold, or ESM-2)?
To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB
