[ccp4bb] Postdoctoral Position at NIH to Study Structures and Mechanisms of Cellular and Viral Noncoding RNAs and RNPs

2019-12-20 Thread Zhang, Jinwei (NIH/NIDDK) [E]
A postdoctoral position is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery and f

Re: [ccp4bb] Potential weak binding ligand in the active site

2019-12-20 Thread Barone, Matthias
Hi Katherine I'm regularly struggling with inhibitors that bound at non-canonical sites and bind there with different conformations. So the situation in these complex-structures could be a bit similar to your situation. In our case, the inhibitors bind on the non-canonical site with roughly Kd

[ccp4bb] CCP4 Crystallographic School in South Africa 2020

2019-12-20 Thread Carmien Tolmie
Dear CCP4bb community, We are pleased to announce the CCP4 Crystallographic School in South Africa, to be held from 31 March — 08 April 2020 at the University of Cape Town, South Africa. The workshop will cover all aspects of protein structure solution by X-ray crystallography, including the fund

Re: [ccp4bb] Potential weak binding ligand in the active site

2019-12-20 Thread 00000c2488af9525-dmarc-request
Hello, the statistics all look good apart from the R-merge and R-meas. It might be worth looking at the processing again in case it can be improved. I assume you mean rms rather than A when you say the difference density only disappears at 6 A and, if so, it must be a strong feature. Does the fragm

Re: [ccp4bb] ftp://strucbio.biologie.uni-konstanz.de/pub down?

2019-12-20 Thread Kay Diederichs
Hi Johannes, thanks for the heads-up! We moved the FTP directory to the webserver that runs XDSwiki and CCP4wiki, and in the process we forgot to set the (freshly installed) FTP server daemon to auto-restart upon boot. This is fixed now. thanks again, Kay On Fri, 20 Dec 2019 11:22:55 +0100, J

[ccp4bb] two years postdoctoral fellowship, deadline for sending the application 22/01/2020

2019-12-20 Thread Benini Stefano
Dear All, We have a call for a two years postdoc (24k€ a year) for candidates holding a PhD and with experience in protein purification (experience in cloning is desirable but not strictly required) to carry out: Protein purification and crystallization, structural and functional characterizat

[ccp4bb] Call open for LTP and BAG beamtime at DESY beamline P11, PETRA III, Deadline: 20.01.2020

2019-12-20 Thread Anja Burkhardt
Dear all, Hereby I would like to invite the submission of Long-Term Projects (LTP) and Block Allocation Group (BAG) proposals for DESY beamline P11 at the PETRA III synchrotron in Hamburg. The call is open until Monday, 20 January 2020 (until midnight local Hamburg time, UTC+1) and relates to

[ccp4bb] Open position for a Biochemist/Crystallographer at FoRx Therapeutics

2019-12-20 Thread Sotirios K. Sotiriou
Dear All, FoRx Therapeutics is a recently incorporated privately-held company based in Basel, Switzerland. It is backed by a syndicate of investors that include the Novartis Venture Fund, Pfizer Ventures, M Ventures, Omega Funds and LSP Venture Capital. FoRx Therapeutics focuses on drugging

[ccp4bb] Job Advert, University of Leeds

2019-12-20 Thread Goldman, Adrian
Hi, I have a 3-year postdoctoral position in my laboratory at Leeds for a structural biologist (broadly defined) to continue our work on integral membrane pyrophosphatases (Kellosalo et al., Science, 337 p473 (2012); Li et al., Nature Comm, 7, 13596 (2016); Vidilaseris et al., Sci Adv 5, eaav75

[ccp4bb] PDBe workshop: Making the most of PDB data with our new graph database

2019-12-20 Thread David Armstrong
Are you looking to use PDB data more effectively to answer complex scientific questions? Do you have experience of accessing data programmatically, but want to more easily create complex data queries? Then you will be interested in our EBI training workshop on accessing PDBe and PDBe-KB data us

[ccp4bb] open positions at Astex

2019-12-20 Thread Gabor Bunkoczi
Dear All, Astex has multiple positions open within the Molecular Sciences group based in Cambridge, UK. Software developer/X-ray crystallography: http://astx.com/wp-content/uploads/2019/12/Xray-Software-Developer.pdf Structural biologist/protein scientist: http://astx.com/wp-content/uploads/20

[ccp4bb] ftp://strucbio.biologie.uni-konstanz.de/pub down?

2019-12-20 Thread Johannes Cramer
Dear collegues, I am trying to install xdsgui, however, I cannot access any files on the ftp server ftp://strucbio.biologie.uni-konstanz.de/pub. https://www.isitdownrightnow.com/ suggests, that it is not just me, but the server is really down. Does anyone have information about whether or when the