Re: [Bioc-devel] dealing with GRCh38 build

2014-07-28 Thread Vincent Carey
Thanks Marc, this is good to know. We need to have the hg38 objects ready for general use -- there is nothing custom about using the same build as NHGRI. I wouldn't say there's a huge rush but there is a need for both a solution and a policy that addresses the management of an environment where a

Re: [Bioc-devel] dealing with GRCh38 build

2014-07-28 Thread Marc Carlson
Hi Vince, The current Homo.sapiens package/object contains a reference to an hg19 TranscriptDb object (which makes it specific to hg19). But you can easily make a custom Homo.sapiens object of your own that points to a custom TranscriptDb object. Making a custom OrganismDbi object is easy t

Re: [Bioc-devel] dealing with GRCh38 build

2014-07-28 Thread Vincent Carey
I confirmed that the rtracklayer liftOver will work with the appropriate chain. the remap utility seems to have some more configurability. might be worth a look. What I need to do promptly is put the proper seqinfo on result of makeCurrentGwascat so that folks are not led astray. We also need g

[Bioc-devel] dealing with GRCh38 build

2014-07-28 Thread Vincent Carey
I just noticed that the addresses for NHGRI GWAS catalog distribution are relative to GRCh38. Is there a plan for using Homo.sapiens with selection of build? It may not be uncommon for someone to want to work with different builds. What would be useful for me at this time is a simple way to get