[NMusers] single-patient AUC

[markus joerger]

dear NM-community,

Is NONMEM reliably used for single-patient AUC-calculation in cases of
linear PK, or is e.g. WinNonLin (or similar software) preferred in such
cases?

best regards,
Markus



-- 
Markus Joerger MD PhD
Associate Professor
Medical Oncology&Clinical Pharmacology
Cantonal Hospital
9007 St. Gallen
Switzerland
markus.joer...@kssg.ch
markus.joer...@gmail.com
Phone: +41-765591070
Fax: +41-714946325

Re: [NMusers] single-patient AUC

[Denney, William S.]

Hi Markus,

Typically, AUCs are calculated using software like WinNonlin because it is both 
simpler and more objective (the model is simple and specified a priori).  
Generally, the model is just used as the linear-up, log-down trapezoidal rule 
with personal (or corporate) preferences on handling BLQ and extrapolation to 
infinity.

Thanks,

Bill

On Sep 1, 2012, at 11:13 PM, "markus joerger" 
mailto:markus.joer...@gmail.com>> wrote:

dear NM-community,

Is NONMEM reliably used for single-patient AUC-calculation in cases of linear 
PK, or is e.g. WinNonLin (or similar software) preferred in such cases?

best regards,
Markus



--
Markus Joerger MD PhD
Associate Professor
Medical Oncology&Clinical Pharmacology
Cantonal Hospital
9007 St. Gallen
Switzerland
markus.joer...@kssg.ch
markus.joer...@gmail.com
Phone: +41-765591070
Fax: +41-714946325

RE: [NMusers] single-patient AUC

[Mats Karlsson]

Dear Markus,

 

I guess it depends on how you plan to make the estimation:

1)  If it is by NCA, other programs will do this 

2)  If it is as model-based, non-linear regression, many programs will
do it (incl NONMEM)

3)  If you want to analyse the individual data using a previous
population PK model as prior, NONMEM and other non-linear mixed effects
models are probably preferable.

Best regards,

Mats

 

Mats Karlsson, PhD

Professor of Pharmacometrics

 

FIRST WORLD CONFERENCE ON PHARMACOMETRICS, 5-7 September 2012, Seoul (
 www.go-wcop.org)

 

Dept of Pharmaceutical Biosciences

Faculty of Pharmacy

Uppsala University

Box 591

75124 Uppsala

 

Phone: +46 18 4714105

Fax + 46 18 4714003

 

From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of markus joerger
Sent: 02 September 2012 04:40
To: NONMEM
Subject: [NMusers] single-patient AUC

 

dear NM-community,

Is NONMEM reliably used for single-patient AUC-calculation in cases of
linear PK, or is e.g. WinNonLin (or similar software) preferred in such
cases?

best regards,
Markus 



-- 

Markus Joerger MD PhD
Associate Professor
Medical Oncology&Clinical Pharmacology
Cantonal Hospital

9007 St. Gallen
Switzerland
markus.joer...@kssg.ch
markus.joer...@gmail.com
Phone: +41-765591070
Fax: +41-714946325