Re: [ccp4bb] honeybee repair?

2018-12-19 Thread Ulrike Demmer 
Hi Jon,

here in Germany we got the Honey Bee installed by Zinsser Analytic.
May be they are still doing the service .

http://www.medicalexpo.de/prod/zinsser-analytic/product-70627-771591.html

You have to scroll down the page a bit to find Zinsser. 

Good luck !

Ulrike



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[ccp4bb] Structural Biology Vacancy UK - Plastic-digesting enzymes

2018-12-19 Thread John McGeehan 
Dear Colleagues,

We have a 4-year Senior Research Fellowship open within our newly
developing Centre of Enzyme Innovation (CEI
)
at the University of Portsmouth, UK. We are looking for a talented
structural biologist with an interest in the characterisation of enzymes
and their modification for improved function through protein engineering.
We are focused on biological catalysts for the depolymerisation of polymers
from natural (eg. lignocellulose) and synthetic (plastics such as PET)
sources.

Publications from our group this year include our work on PETase (
https://www.pnas.org/content/115/19/E4350) and a new class of cytochrome
P450 for the bioconvertion of lignin (
https://www.nature.com/articles/s41467-018-04878-2).

The salary range is £39-48k (up to $60k USD) and the closing date for
applications is at the end of January. Details of the job can be found here:
https://www.nature.com/naturecareers/job?id=669251

Best Regards,
John
-- 
*Professor John McGeehan*
--
Centre for Enzyme Innovation (web
),
Institute of Biological and Biomedical Sciences (web
),
School of Biological Sciences,
University of Portsmouth,
King Henry Building,
PO1 2DY, UK
--
Email: john.mcgee...@port.ac.uk
Tel:+44 (0) 2392 842042


*PA: Jacky Dillon *
Email: jacky.dil...@port.ac.uk
Tel: +44 (0) 23 92842023



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[ccp4bb] Postdoc position (X-ray and/or Cryo-EM) to study RNA silencing

2018-12-19 Thread 
Dear colleagues,

The Nakanishi lab is looking for a self-motivated structural biologist 
interested in elucidating the molecular mechanisms of diversified RNA silencing 
by human Argonaute proteins and their binding partners. The position is 
available immediately and will remain open until filled.

MicroRNAs and other small RNAs are loaded into different Argonaute proteins to 
form unique effector complexes, regulating many biological processes. Humans 
have four Argonaute paralogs, each of which is responsible for specialized 
roles. Our focus is to understand the molecular bases for their unique RNA 
silencing. To this end, we take a combinatorial approach of molecular biology, 
biochemical and biophysical methods, and structural biology (crystallography 
and cryo-EM). Candidates should have a strong background and expertise in X-ray 
crystallography or single-particle electron microscopy and the biochemical 
experiments. Applicants with experience in RNA biology will be stronger 
candidates. New Ph.D. graduates are encouraged to apply.

My group has a great environment to pursue goals. We own multiple AKTA FPLC 
systems and an automatic crystal plate imaging system. We have access to OSU 
Campus Chemical Instrument Center in the same building that has a 
crystallization robot (Mosquito) and a laboratory-scale X-ray diffractometer 
(Rigaku MicroMax-003 with a Pilatus 200K detector). We remotely carry out our 
crystallographic experiments at The Advanced Photon Source. The Ohio State 
University has a state-of-the-art cryo-EM facility, CEMAS (URL: 
https://cemas.osu.edu), that is located within a 5 min driving distance from my 
lab. There is a Titan Krios with a K3 Bioquantum direct electron detector, 
imaging phase plates, STEM/TEM tomography, and an image spherical aberration 
corrector. 

Interested candidates should email a cover letter describing their research 
experience, a curriculum vitae, and the names of three references (one should 
be the current supervisor) to nakanish...@osu.edu.

Best,
Kotaro


Kotaro Nakanishi, Ph.D.
Assistant Professor
Department of Chemistry & Biochemistry
The Ohio State University
742 Riffe Building,
496 W 12th Avenue
Columbus, OH 43210-1292
Tel: (614)-688-2188
E-mail: nakanish...@osu.edu
Web:  http://u.osu.edu/nakanishilab/
Twitter: https://twitter.com/nakanishi_lab



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[ccp4bb] Positions at Institute For Protein Innovation » Postdoctoral Fellows (Innovation, Discovery, & Entrepreneurial)

2018-12-19 Thread IPI Careers 
*Postdoctoral Fellows (Innovation, Discovery, & Entrepreneurial)*


*Employer*: Institute for Protein Innovation

*Location*: Boston, Massachusetts (US)

*Salary*: $50,000-$70,000

*Discipline*: Life Sciences, Biochemistry, Bioengineering, Biomedical
Engineering, Biophysics, Biotechnology, Computational Biology, Immunology,
Proteomics, Structural Biology, Health Sciences, Drug Discovery

*Position Type*: Full Time

*Organization Type*: NonProfit

*Job Type*: Postdoc, Postdoc Fellowship



Institute for Protein Innovation (IPI) aims to equip the next generation of
scientist-entrepreneurs with the skills and knowledge to ensure successful
careers as academics, industrial scientists, and entrepreneurs. We are
looking for highly motivated, scientifically curious, and intellectually
creative candidates to train as *Innovation Postdoctoral Fellows, Discovery
Postdoctoral Fellows,* and* Entrepreneurial Fellows*.



*Innovation Postdoctoral Fellows.*

Innovation Fellows will work with Platform leaders and affiliated IPI
faculty to develop novel technologies, platforms, and approaches in protein
science. Examples include improving antibody discovery platforms,
engineering novel properties into proteins, developing new methods for
identifying receptor-ligand pairs, and creating novel platforms for protein
expression or drug discovery. Research must be fully publishable.



*Discovery Postdoctoral Fellows.* Discovery Fellows will work with Platform
leaders and affiliated IPI faculty to use IPI platforms for discovery of
new biological principles. Examples include discovery of new biological
pathways or interactions, antibodies to target proteins for which good
reagents are not currently available that enable discovering novel
functional properties, partners of target proteins, and potential lead
therapeutics. Research must be fully publishable.



*Entrepreneurial Fellows.* Successful Innovation or Discovery Postdoctoral
Fellows can transition to Entrepreneurial Fellows. The purpose of these
fellowships is to allow technical innovations or discoveries to be
developed sufficiently to enable a career in Academia, patents, or company
formation.



*Qualifications*:


   - Ph.D. in Biochemistry, Biophysics, Engineering or related field
   - Demonstrated track record of publications and productivity

Please send applications to careers[@]proteininnovation.org. Applications
should include: a cover letter, CV/resume, list of three references, and
“CCP420181219” in the subject line.



IPI offers competitive compensation and benefits, including health and
dental insurance, generous vacation and holiday time off, and retirement
saving plans. IPI is an Equal Opportunity / Affirmative Action Employer.
Qualified applicants will receive consideration for employment without
regard to their race, color, religion, national origin, sex, sexual
orientation, gender identity, protected veteran status or disability.




*About the Institute*

IPI is a nonprofit research organization whose mission is to foster
innovation in protein research, train the next generation of innovators and
entrepreneurs in protein science, forge new ties between academic and
industry investigators, and bridge the missing link between genomics and
therapeutics. IPI has built a high-throughput antibody discovery platform
for developing open-source antibodies targeting the entire human
extracellular proteome. This resource will produce critical tools, lead
therapeutics, and technologies that empower academic and industry
scientists, catalyze entrepreneurship, and accelerate drug discovery.



For more information about IPI: proteininnovation.org.

-- 

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