[ccp4bb] Membrane Protein Postdoctoral Fellowships at Novartis Institutes for Biomedical Research, Cambridge, MA

[Tim Benson]

NIBR Presidential Postdoctoral Fellowships 

Would you like to contribute to innovative research with the goal of improving 
human health? Novartis Institutes
for BioMedical Research has a variety of postdoctoral positions in biology, 
chemistry and computational sciences that provide excellent training in 
research and exposure to science in a pharmaceutical setting.

The NIBR Presidential Postdoctoral Fellowships provide scientists with a unique 
opportunity to conduct innovative, interdisciplinary basic research in an 
industry setting. Presidential Fellows have a NIBR mentor and an academic 
mentor, and develop their projects in consultation with both mentors. PhD 
students in the last year of their doctoral research, as well as postdoctoral 
fellows with fewer than two years of research experience past their PhD, are 
eligible to apply. Applications are accepted on a rolling basis. All 
fellowships are for a three-year term.

Membrane Protein Postdoctoral Fellowships in the Center for Proteomic 
Chemistry, Cambridge, MA

We are currently seeking candidates for two membrane protein structural biology 
postdoctoral positions in the laboratories of Ian Hunt and Timothy E. Benson, 
specifically to be focused furthering our understanding of pharmaceutically 
relevant human ion channels targets.

Candidates should have a high interest in biochemical, biophysical and 
structural investigation of ion channels and its applicability to the drug 
discovery process.  Candidates should possess strong interpersonal skills and 
enjoy working in a matrix driven organization.  The successful candidate will 
conduct research alongside a dynamic team of researchers leveraging structural 
and biophysical studies of protein-ligand complexes to impact early drug 
discovery. 

Prior experience required in protein expression (insect cell, mammalian, 
yeast), protein purification, and/or protein structure (crystallization, data 
collection, structure determination).  Experience with membrane proteins, 
biophysical characterization of protein-ligand complexes (e.g. SPR, DSF), 
and/or electrophysiology would be a significant plus.

For more information and to apply, please visit 
http://nibr.com/careers/postdocs.shtml and reference this posting.

Novartis is an equal opportunity employer committed to embracing and leveraging 
diverse backgrounds. M/F/D/V.

[ccp4bb] Two postdoctoral positions available at The Institute of Cancer Research, London/Sutton, UK

[Rob VanMontfort]

The Institute of Cancer Research (ICR) is one of the world’s most influential 
cancer research institutes. Our mission is to make the discoveries that defeat 
cancer. We have a long and distinguished history of research with a major 
impact on the outcome for cancer patients. Our unique partnership with The 
Royal Marsden NHS Foundation Trust (RMH) makes us the largest comprehensive 
cancer centre in Europe, performing high quality original basic research and 
translational studies. The ICR was ranked as the UK’s top academic research 
centre in the 2008 Higher Education Funding Council Research Assessment 
Exercise.
The Cancer Research UK Cancer Therapeutics Unit (CTU), embedded within the 
Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' 
centre, comprising around 160 staff dedicated to the discovery and development 
of novel therapeutics for the treatment of cancer. The CTU’s exciting goal is 
to discover high quality drug candidates for validated biological targets and 
to progress these candidates to clinical trial. All the scientific disciplines 
are in place to make this possible, including medicinal chemistry, biology, 
drug metabolism and clinical specialists.
Two postdoctoral positions are available in Dr Rob van Montfort’s Hit Discovery 
and Structural Design (HDSD) Team within the CTU:
A postdoctoral position in protein crystallography is available from June 7th 
2012 (Ref: 1238145). The Post-doc will be involved in high-throughput X-ray 
crystallography, fragment-based screening and structure-based drug design and 
will be responsible for crystallisation and structural analysis of 
protein-ligand complexes from the CTU’s drug discovery programmes. The 
successful candidate will interact closely with the biology, computational 
chemistry and medicinal chemistry teams at the CTU as well as with the protein 
crystallographers in the Division of Structural Biology in which the 
crystallography efforts of Dr van Montfort’s team are embedded. Therefore the 
successful candidate will be expected to work across the two sites in Chelsea, 
London and Sutton, Surrey. Applicants must have a PhD in a biological or 
physical science, and experience in macromolecular crystallography (to include 
protein biochemistry, protein crystallisation, & protein crystallography). 
Experience in molecular biology, protein purification, and/or structure-based 
drug design will be an advantage.
We are also seeking a highly motivated postdoctoral training fellow with 
experience in Surface Plasmon Resonance (SPR) to join the team (Ref: 1238162). 
The successful candidate is expected to develop the SPR expertise within the 
team and study the kinetics of inhibitor binding to the targets in the Unit’s 
portfolio. Using the team’s Biacore T200 SPR equipment, the postdoctoral fellow 
will carry out SPR fragment screening as well as detailed kinetic 
characterisation of inhibitors for a number of target classes (including 
kinases, ATPases, DNA repair and epigenetic enzymes). The successful candidate 
will impact on specific drug discovery projects within the portfolio as an 
integral member of the project team and will interact closely with the 
biologists, computational chemists, medicinal chemists and structural 
biologists. Applicants must have a PhD in a biochemistry or related biological 
subject and experience in Surface Plasmon Resonance methodologies. In addition, 
a strong experience in protein expression and purification is essential.
The starting salary for the positions will be in the range £27,536 to £38,225 
p.a. inclusive (based on previous post-doctoral experience) and the posts are 
offered on a fixed term contract of 2 years. Informal enquiries to 
rob.vanmontf...@icr.ac.uk or 
isaac.westw...@icr.ac.uk. Please DO NOT send 
your application to Dr van Montfort or Dr Westwood; applications must be 
submitted in line with the instructions on our website: http://www.icr.ac.uk. 
Closing date April 10th 2012.
Dr. Rob van Montfort
Team Leader Hit Discovery and Structural Design
Sections of Cancer Therapeutics and Structural Biology
The Institute of Cancer Research
15 Cotswold Road
Sutton SM2 5NG
UK

Tel:
+44-(0)20-8722-4364 (Sutton)
+44-(0)20-7153-5142 (Chelsea)
Email: rob.vanmontf...@icr.ac.uk


The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company 
Limited by Guarantee, Registered in England under Company No. 534147 with its 
Registered Office at 123 Old Brompton Road, London SW7 3RP.

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[ccp4bb] Postdoctoral Fellowship in Protein Crystallography

[Seth Rubin]

A Postdoctoral Fellow position is available immediately in the  
laboratory of Professor Seth Rubin at the University of California,  
Santa Cruz.  Our research focuses on the structural biology and  
biochemistry of cell cycle regulation and cancer.  Immediate future  
plans include structural studies of a large, multisubunit complex  
with function in chromatin regulation. A Ph.D. in biochemistry or  
molecular biology with experience in expression, purification, and  
crystallization of protein complexes is preferred.  This position is  
an excellent opportunity to develop one’s molecular biology  
perspective while working in an energetic, interdisciplinary  
environment on Monterey Bay in California.



Please refer to http://www.chemistry.ucsc.edu/~srubin and apply to  
sru...@ucsc.edu.