When I first got my Sam frameset, I used various bits and pieces I had 
laying around to build it up and ride it before I knew exactly what I 
wanted. This included running an Ultegra 6600 10-speed drivetrain & 
brifters on it which I had laying around unused. While it wasn't a typical 
Sam build, everything integrated just fine. I slowly swapped out most of 
the Ultegra parts but ran the hollowtech Ultegra crankset on it for almost 
a year, despite going to a 9-speed 12-36 cassette, Deore RD, and bar-end 
shifters. (I also used the brifters only as brake levers for a bit).

It'll take the modern stuff just fine. 

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