> From: jlu...@ria.buffalo.edu > > Clearly inferior treatments are unethical.
The Big Question is: What constitute "clearly"? Who or How to decide what is "clearly"? I'm sure there are plenty of people who don't understand much Statistics and are perfectly willing to say the results on the two cousins show the conventional treatment is "clearly inferior". Sure, on these two cousins we can say so, but what about others? > Donald Berry at MD Anderson in Houston TX and Jay Kadane at Carnegie > Mellon have been working on more ethical designs within the Bayesian > framework. In particular, response adaptive designs reduce > the assignment > to and continuation of patients on inferior treatments. I've heard LJ Wei talked about this kinds of designs (don't remember if they are Bayesian) more than a dozen years ago. Don't know how common they are in use. Andy > > > Bert Gunter <gunter.ber...@gene.com> > Sent by: r-help-boun...@r-project.org > 09/20/2010 01:31 PM > > To > r-help@r-project.org > cc > > Subject > [R] OT: Is randomization for targeted cancer therapies ethical? > > > > > > > Hi Folks: > > **Off Topic** > > Those interested in clinical trials may find the following of > interest: > > http://www.nytimes.com/2010/09/19/health/research/19trial.html > > It concerns the ethicality of randomizing those with life-threatening > disease to relatively ineffective SOC when new "biologically targeted" > therapies "appear" to be more effective. While the context may be new, > the debate, itself, is not: Tukey wrote (or maybe it was talked -- I > can't remember for sure) about this about 30 years ago. I'm sure many > other also have done so. > > Cheers, > > Bert > -- > Bert Gunter > Genentech Nonclinical Biostatistics > > ______________________________________________ > R-help@r-project.org mailing list > https://stat.ethz.ch/mailman/listinfo/r-help > PLEASE do read the posting guide > http://www.R-project.org/posting-guide.html > and provide commented, minimal, self-contained, reproducible code. > > > [[alternative HTML version deleted]] > > ______________________________________________ > R-help@r-project.org mailing list > https://stat.ethz.ch/mailman/listinfo/r-help > PLEASE do read the posting guide > http://www.R-project.org/posting-guide.html > and provide commented, minimal, self-contained, reproducible code. > Notice: This e-mail message, together with any attachme...{{dropped:11}} ______________________________________________ R-help@r-project.org mailing list https://stat.ethz.ch/mailman/listinfo/r-help PLEASE do read the posting guide http://www.R-project.org/posting-guide.html and provide commented, minimal, self-contained, reproducible code.
