On Sep 20, 2010, at 2:28 PM, Charles C. Berry wrote:
On Mon, 20 Sep 2010, Bert Gunter wrote:
Hi Folks:
**Off Topic**
Those interested in clinical trials may find the following of
interest:
http://www.nytimes.com/2010/09/19/health/research/19trial.html
It concerns the ethicality of randomizing those with life-threatening
disease to relatively ineffective SOC when new "biologically
targeted"
therapies "appear" to be more effective. While the context may be
new,
the debate, itself, is not: Tukey wrote (or maybe it was talked -- I
can't remember for sure) about this about 30 years ago. I'm sure many
other also have done so.
Anscombe's remarkable (and influential) review of Armitage's
'Sequential Medical Trials' back in 1963
http://www.jstor.org/stable/2283272
Not all university libraries have access via that link and efforts at
identifying the citation in Pubmed failed, so could I request a more
complete citation, please? Oh never mind I got it with Google. If
anyone else needs the ISSN of JASA in which both the cited article and
Armitage's reply appeared for the purposes of JSTOR access, it's
01621459.
Sequential Medical Trials
F. J. Anscombe
Journal of the American Statistical Association
Vol. 58, No. 302 (Jun., 1963), pp. 365-383
Published by: American Statistical Association
http://www.jstor.org/stable/2283272
Sequential Medical Trials: Some Comments on F. J. Anscombe's Paper
P. Armitage
Journal of the American Statistical Association
Vol. 58, No. 302 (Jun., 1963), pp. 384-387
(article consists of 4 pages)
URL: http://www.jstor.org/stable/2283273
--
David.
is worth a look by any statistician who is interested in this topic.
It makes explicit several factors that weigh in the ethical
assessment of a particular trial design.
He discusses in formal terms the weighing of outcomes for patients
in the trial at hand aginst those of future patients and the impact
that this might have on design decisions.
HTH,
Chuck
Cheers,
Bert
--
Bert Gunter
Genentech Nonclinical Biostatistics
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Charles C. Berry (858) 534-2098
Dept of Family/Preventive
Medicine
E mailto:cbe...@tajo.ucsd.edu UC San Diego
http://famprevmed.ucsd.edu/faculty/cberry/ La Jolla, San Diego
92093-0901
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David Winsemius, MD
West Hartford, CT
______________________________________________
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