230 UI screens is a lot. An app of that nature is not something people commonly do in Python (although I would be happy to see people show me wrong). You are building a GUI app that likely need not run anywhere except on Windows and perhaps most what of what is does is edit and report on data from the database. This is the very task 4GL tools like Visual Basic were created for.
VB6 has certainly been outdated for quite a while ago now and you should probably make the switch but don't discount the tools that exactly specialize in this domain such as Visual Studio.NET and Delphi. Python is a great general purpose language but the above tools are leaps and bounds ahead of the tools available to Python in this very specific domain. Additionally your team already is familiar with the RAD paradigm. As easy as Python is, it takes a while to develop expertise in a new language and it's paradigms (especially when it is such a leap - VB and Python are almost at the opposite ends of the spectrum). IronPython has a lot of promise but is not mature enough yet to bet a project large enough to take 2 years (or more) to develop. At that project size, it is not sane to attempt anything adventurous unless you have have enough funds to buffer when things go wrong. I am not recommending against Python, just to plan VERY VERY carefully on what you embark on. Start using Python gradually in your development. Refactor some functionality into COM components for starters to simplify your VB code. When Python is doing much of the heavy lifting, you are ready to make the change. By the time you are ready to make the full switch, you will know. Personally, for a project like this, I would go with Borland Studio (it has ECO which is a tremenduous advantage for data driven GUIs) and supplement it with Boo (a Python like language for .NET). -- http://mail.python.org/mailman/listinfo/python-list
