[troll]
For a serious web based MMO you'd rather stick to low level and forget about 
bloated Object Relational Mapping java-like layered kind of frameworks that are 
made for Rapid Applications Development, not for efficiency.
[/troll]

"Eve Online", a well known MMORPG was developped with stackless python : 
http://highscalability.com/eve-online-architecture

You mentioned nginx so I can tell you I personally use Linux + nginx + mongodb 
(pymongo) + Python 3 version of cherrypy (with Mako templates) and it's working 
fine after some tuning.
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