Tim Peters added the comment:

By the way, if memory serves, compiling with --with-pydebug changes the memory 
layout of Python objects, so a Python compiled this way _cannot_ be used 
successfully with extension modules that were compiled without the same 
options.  Did you rebuild your extensions too?

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Python tracker <rep...@bugs.python.org>
<http://bugs.python.org/issue18843>
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