Antoine Pitrou added the comment:

A proof of concept hack to enable framing on pickle showed a massive 
performance increase on streaming unpickling (up to 5x faster with a C file 
object such as io.BytesIO, up to 150x faster with a pure Python file object 
such as _pyio.BytesIO). There is a slight slowdown on non-streaming operation, 
but that could probably be optimized.

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<http://bugs.python.org/issue17810>
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