Serhiy Storchaka added the comment:

Memoization consumes memory during pickling. For now every memoized object 
requires memory for:

dict's entity;
an id() integer object;
a 2-element tuple;
a pickle's index (an integer object).

It's about 80 bytes on 32-bit platform (and twice as this on 64-bit). For data 
which contains a lot of floats it can be cumbersome.

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Python tracker <rep...@bugs.python.org>
<http://bugs.python.org/issue17810>
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