I have used the 2i4 a bit and briefly the Scarlet solo. The 6i6 as I understand 
it is the 2i4 with 2 more line inputs and digital I/o. Unlike the 2i4 however, 
the 6i6 requires drivers. (The 2i4 doesn’t and as a result is quite accessible 
since all I/O task are handled from with in the DAW), and it has physical 
buttons for switching  the line inputs between line and instrument right on the 
device. It appears the 6i6 doesn’t and you will have to switch between line and 
instrument in the Focusrite Control software., That being said, Focusrite 
support is good about Remoting into your system to help you set stuff up if 
needed, but if you want to record  say a guitar or bass through the DI often it 
can be a pain having to switch via software. That being said, the iOS app 
worked decently well for stuff like that with the Clarett range and the 6i6 
looks to use the same iOS app for control, however you will need sighted 
assistance to pair the iOS app to the app running on your Mac at least once. 
This may be blasphemous  to some but I have to  mention if you don’t need the 
digital I/O the Behringer U-Phoria 404HD is about $100 cheaper and comparable 
in sound to the scarlet unit.  It has 4 Mic Press which can be also used as 
line or instrument inputs. The line/instrument level switch, the pad, and 
phantom power are all physical buttons on the unit and no software or drivers 
are required, it is very stable and runs rock solid even down at 32 samples 
when tracking with low latency. The only other caveat is that the 404HD only 
has one headphone jack where the 6i6 has 2. I have sound examples comparing the 
two units side by side if interested. 

> On Mar 15, 2019, at 10:49 PM, Ronald J Glaser <[email protected]> 
> wrote:
> 
> has anyone used this particular audio interface?
> 
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