> Applicable snippets from files are:
>  
> My main.cf
>  
>  
> content_filter=smtp-amavis:[127.0.0.1]:10024 meta_directory = /etc/postfix
>  
> smtp_tls_security_level = may
> smtpd_tls_security_level = may
>  
>  
>  
> I did this to master.cf
>  
> 127.0.0.1:2510 inet n       -       n       -       -       smtpd
> -o syslog_name=postfix/submission
> -o smtpd_tls_security_level=encrypt
> -o smtpd_sasl_auth_enable=yes
> -o smtpd_client_restrictions=permit_sasl_authenticated
> -o milter_macro_daemon_name=ORIGINATING
> -o content_filter=

check if those lines are beginning with whitespace (tab/space):

127.0.0.1:2510 inet n       -       n       -       -       smtpd
  -o syslog_name=postfix/submission
  -o smtpd_tls_security_level=encrypt
  -o smtpd_sasl_auth_enable=yes
  -o smtpd_client_restrictions=permit_sasl_authenticated
  -o milter_macro_daemon_name=ORIGINATING
  -o content_filter=

Depending on the mail-/logvolume on the server you might temporarily
set "  -o syslog_name=postfix/submission2510" to distinguish
submission (587) and submission (2510).


> My  PHPList config.php file shows
>  
> define('PHPMAILERHOST', '127.0.0.1');
> define('PHPMAILERPORT',2510);
> define('PHPMAILER_SECURE',true);

If connections are originating from localhost only, you don't
need encryption (PHPMAILER_SECURE / "-o smtpd_tls_security_level=encrypt").

With encryption you need to check if PHPMAILER verifies certificates
and if verification is successful. Usually this requires a certificate
signed by a certification authority like letsencrypt. Self-signed
certificates can be problematic in this context.

> Apr 25 08:52:08 mcq postfix/submission/smtpd[18972]: lost connection after 
> STARTTLS from localhost[127.0.0.1]

This might be a hint that validation is not successful - PHPMAILER drops the 
connection.
Perhaps you can enable a debug log in PHPMAILER for more information.

Best regards,
Gerald


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