Sep 28 15:11:23 nmail spamc[4525]: connect to spamd on 127.0.0.1
failed, retrying (#1 of 3): Connection refused
Sep 28 15:11:23 nmail spamc[4525]: connect to spamd on 127.0.0.1
failed, retrying (#2 of 3): Connection refused
Sep 28 15:11:24 nmail spamc[4525]: connect to spamd on 127.0.0.1
failed, retrying (#3 of 3): Connection refused
Step one, is spamassasin running?
`ps aufx`
Step two, is it listening where you think it is and is the port it is
listening on the port being tried?
`netstat -nlp46`
Step three, any odd firewall rules preventing connection? Highly
unlikely considering localhost is nearly never blocked, but you never
know. Which then leads to checking selinux rules next.