Thank you, Wietse:
This means that client systems are compromised with malware that sends email directly to the outside world, bypassing your mail server. To stop these, block outbound port 25 on your firewall for all systems except your mail server. Wietse
Is it safe to assume that all legitimate email services, like Outlook.com for example, are going to be using a submission service and not sending directly over port 25, and that blocking port 25 on outgoing connections will not interfere with normal email delivery?
-- Asai