Nikolaos Milas:
> connect to vmail2.noa.xxx[2001:648:2011:15::xxx]:25: Connection refused; 

This is a TCP-level problem.  The remote server's TCP/IP stack, or
some middle box, is refusing connections at the TCP level.

All Postfix can do is make fewer connections.

To reduce connection concurrency:

- a reduced SMTP client process limit in master.cf, 
  (http://www.postfix.org/master.5.html)

- a reduced transport_destination_concurrency_limit in main.cf,
  
(http://www.postfix.org/postconf.5.html#transport_destination_concurrency_limit)

To reduce the connection rate, if things get really desperate:

- a non-zero transport_destination_rate_delay in main.cf.
  (http://www.postfix.org/postconf.5.html#transport_destination_rate_delay)

        Wietse

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