Alex:
> Hi,
> 
> I'm using postfix-3.5.7 on fedora32 on a server with four IP addresses
> (mail1, mail2, etc) on one interface. The problem is that all mail
> goes out the IP associated with the actual interface, not the virtual
> ones, which I believe is causing SPF to fail.
>
> Is this a Linux problem?

No, this is a configuration problem.

> Would I have to have multiple instances of postfix running to be able
> to control which IP is used for which domain?

Give each instance its owninet_inteerfaces setting.

This is covered in
http://www.postfix.org/BASIC_CONFIGURATION_READNE.html

        Wietse

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