Greg Sims:
> Good Morning Wietse,
> 
> The error message is the same in this configuration with ens4
> NM_CONTROLLED="no" using Alias ip addresses:
> 
> rhel8 r193/smtp[4988]: warning: smtp_connect_addr: bind 75.xxx.xxx.193:
> Cannot assign requested address

You claim that you configured the following as additonal interface
addresses:

        74.something

The error message shows that you configured Postfix to bind to:

        75.something

Do you notice the difference?

        Wietse

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