If most recipients are remote. then use relay_domains
and list the remote recipients in relay_recipient_maps.

virtual_alias_maps:
    us...@example.com     user1@localhost

relay_recipient_maps:
    us...@example.com   whatever

transport_maps:
    example.com: [host.example.com]

and relay_domains=example.com

This is the http://www.postfix.org/STANDARD_CONFIGURATION_README.html
gateway example, plus cvirtual aliases for local recipients.

        Wietse

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