Thanks for the replies. I really appreciate the help. I am already leveraging /etc/postfix/virtual to route traffic to my "hosted domains".
The problem I'm trying to solve, simply stated, is that I need to be able to selectively masquerade inbound email to my hosted domains. So, u...@doma.com will see his mail addressed to u...@doma.com, but u...@domb.com might see his mail addressed to u...@myco.com, our canonical domain name.