John:
> While looking at the various Postfix configurations that I deal with I 
> realized that /mynetworks/ is configured identically in all four setups.
> In the three installations I support there no local users, and the 
> people who belonging to those domains all use port submission (587) to 
> send and imaps (993) to receive email.
> The KLaM domain is slightly different in that there local users, however 
> they like the other domains all use 587/993.
> Does /mynetworks/ have to contain anything other than 127.0.0.1/8 and 
> ::1/128.

If in doubt, read the documentation.

mynetworks (default: see postconf -d output)
   The list of "trusted" remote SMTP clients that have more privileges
   than "strangers". [more text omitted]

mynetworks controls the result of using "permit_mynetworks".
I suggest therefore that you examine the output from

    $ postconf | grep mynetworks

(and with Postfix >= 2.9: $ postconf -M | grep mynetworks).

        Wietse

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