I was getting spam that has a simple DNS signature: all the sender domains have A records that resolve to the same IP address. These domains have different MX hosts, and therefore check_sender_mx_access is ineffective.
I added check_xxx_a_access (xxx in client, reverse_client, helo, sender, recipient). This looks up all IP address for the domain name in xxx (both A and AAAA addresses if applicable) and runs the addresses through a standard Postfix access table. This will be released some time next week. Wietse