mikael.bak:
> I found a very useful document about this topic here:
> http://www.postfix.org/MULTI_INSTANCE_README.html
> 
> One thing I fail to understand is how I with multiple postfix instances 
> can determine which queue is used for newsletter and for all the rest. 
> Do I have to configure multiple IP addresses - one for each postfix 
> instance?

Each instance has its own mail queue and scheduler. If an instance
needs to receive mail via SMTP, THEN it needs its own IP address
or TCP port.

To submit mail with the Postfix sendmail command:

/usr/sbin/sendmail -C config-directory-of-alternate-instance ...

Begin quote from Postfix sendmail manpage
       -C config_file

       -C config_dir
              The path name of the Postfix main.cf  file,  or  of  its  parent
              directory.  This  information  is  ignored with Postfix versions
              before 2.3.

              With all Postfix versions, you can specify a directory  pathname
              with  the MAIL_CONFIG environment variable to override the loca-
              tion of configuration files.
End quote from Postfix sendmail manpage

        Wietse

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