On Sat, May 18, 2013 at 11:42:30AM -0700, Umar Draz wrote:

> postmarkapp.com

    http://developer.postmarkapp.com/

    Things You Should Know

        Postmark is for transactional email only. You may not send
        newsletters, announcements to your lists or any other bulk email. If
        you're uncertain if your email qualifies as 'transactional', you can
        always contact support and we'll review your usage.

> mandrillapp.com
> www.mailjet.com
> mailgun.org

Similar considerations may apply to the others.  If you're sending 500,000
messages at once, that does not sound "transactional" to me.

> Now my question is, is this possible? if yes then how?

You can use a different sender address to direct individual messages
to each of the 4 providers via sender dependent relayhost settings.
No promises this will work for very long, as most likely your mail
is spam.

-- 
        Viktor.

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