I run the ping command at the Mail Server the result is as 
below:---root@xn--hadibakalm-5ub:~# ping 65.55.92.184PING 65.55.92.184 
(65.55.92.184) 56(84) bytes of data.64 bytes from 65.55.92.184: icmp_req=1 
ttl=243 time=180 ms64 bytes from 65.55.92.184: icmp_req=2 ttl=243 time=179 ms64 
bytes from 65.55.92.184: icmp_req=3 ttl=243 time=179 ms64 bytes from 
65.55.92.184: icmp_req=4 ttl=243 time=177 ms---But I am sure it is not 
temporary situation because. I am now outside my network and with my remote 
client I can send mail using Icedove relaying to my Mail Server. I have been 
strugling this situation about 10 days but cannot manage to set up correctly. 
My main goal is to send mail using PHP's mail function. But I suppose if I send 
mail from the local server, then the Telnet, PHP is as well could send mail.
> Date: Fri, 13 Jul 2012 12:59:41 +0200
> From: h.rei...@thelounge.net
> To: postfix-users@postfix.org
> Subject: Re: "no route to host"  error message
> 
> 
> 
> Am 13.07.2012 12:39, schrieb Engin qwert:
> > Hello, I set my postfix server using a ready made shell script. The Mail 
> > server is working as excepted except the
> > localhost it self. So the Mail Server can not send mail using Icedove, 
> > Telnet nor PHP' mail () function. When I run
> > "mailq" command the error message is as shown below.
> > --------------
> > 679D8120710      611 Fri Jul 13 12:34:05  some_sender@some_domain.tld
> >                (connect to mx2.hotmail.com[65.55.92.184]:25: No route to 
> > host)
> >                                          some_receip...@hotmail.com
> > --------------
> > Note: I changed the receipent and the sender addresses
> 
> this is clearly a network-layer problem
> what says "ping 65.55.92.184" from this machine and other ones?
> 
> this can vary at different locations and be caused by a temporary
> problem of a router between you and hotmail, that is why a MTA
> treis many times to deliver a message
> 
> from here no problem
> 
> [harry@srv-rhsoft:~]$ ping 65.55.92.184
> PING 65.55.92.184 (65.55.92.184) 56(84) bytes of data.
> 64 bytes from 65.55.92.184: icmp_req=1 ttl=243 time=152 ms
> 64 bytes from 65.55.92.184: icmp_req=2 ttl=243 time=152 ms
> 64 bytes from 65.55.92.184: icmp_req=3 ttl=243 time=149 ms
> 64 bytes from 65.55.92.184: icmp_req=4 ttl=243 time=150 ms
> 64 bytes from 65.55.92.184: icmp_req=5 ttl=243 time=150 ms
> 
                                          

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