Wietse Venema:
> Your symptoms indicate a mis-match between the IN-MEMORY master
> daemon process, and the ON-DISK executable files for smtpd, cleanup,
> etc.

Famous last words. This may be the result of a Linux "misfeature"
where a pipe inode number goes over 32bit:

http://bugs.debian.org/cgi-bin/bugreport.cgi?bug=434851

Try this (with XXXX the master process PID):

    ls -l /proc/XXXX/fd | grep pipe

If the number is >32bit like this:

    l-wx------ 1 root root 64 Jul 27 09:55 100 -> pipe:[4607501403]

Then you need to recompile Postfix with "large file" support
(or use a smaller file system).

        Wietse

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