Many thanks, Sahil and Stan.  Just knowing the right terminology to address the 
situation by is a big help.  I hate to sound like such an amateur but thus far 
I've been focusing my Sysadmin work on everything except email administration, 
so it's been an uphill battle.

Thanks again folks, this should get the ball rolling again.

-J Fox

Sahil Tandon wrote:
On Wed, 27 Jan 2010, Javier Fox wrote:

-MX for domain points to the spam filtering appliance -Appliance
handles user verification (via ldap), rejection, quarantine, etc
-'Clean' mail handed off to MTA for final delivery

The slightly funky part is that there are a number of destination MTA
servers, each servicing a subset of domains and mailboxes.  A
configuration setting on the Appliance maps each domain to its
destination MTA server.

Is it possible to set up Postfix as a drop-in replacement for this
appliance?  Can I tell it "here are the domains to accept mail for,
here is an LDAP full of mailboxes to accept, and here is a hash/sqldb
mapping each domain to its destination MTA"

Yes.  You can use transport_maps to direct mail for different
mailboxes/domains to specific nexthops.  Some documentation to get you
started:

 http://www.postfix.org/STANDARD_CONFIGURATION_README.html
 http://www.postfix.org/ADDRESS_CLASS_README.html
 http://www.postfix.org/ADDRESS_REWRITING_README.html
 http://www.postfix.org/transport.5.html

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