I have a couple of mail servers that act only as SMTP relay, and SMTP backup 
servers.

How can I reject invalid recipient addresses at these servers?

I have investigated the manual on local_recipient_maps, however it appears 
that this is only useful for email where the machine involved is the final 
destination.

In this case these 2 machines operate in a load-balanced manner, forwarding 
email onto the final server, or in a few instances acting as an MX20 backup.

I can make available to these servers (via SQL replication) a list of 'valid' 
email addresses from the destination mail server(s), how can the 
valid/invalid address accept/deny be deployed?

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