Laura Smith via Postfix-users:
> Following a Debian Bookworm update I am now seeing connectivity issues that 
> were not present before (everything was working perfectly before)
> 
> Postfix on the instance starts up fine, i.e. indicating no configuration 
> errors.
> 
> The error is:
> $ openssl s_client -connect [IPV6_ADDRESS_REDACTED]:25 -starttls smtp
> 80BB62673F7F0000:error:8000006F:system library:BIO_connect:Connection 
> refused:../crypto/bio/bio_sock2.c:114:calling connect()
> 80BB62673F7F0000:error:10000067:BIO routines:BIO_connect:connect 
> error:../crypto/bio/bio_sock2.c:116:
> connect:errno=111

Perhaps Postfix does not "listen" on the IPv6 address? You can use nc or lsof
to find out.

        Wietse
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