Barbara M. via Postfix-users:
> Jan 23 00:11:34 auth postfix/smtpd[188544]: NOQUEUE: reject: RCPT from 
> wp-host1.xyz.com[4.3.2.1]: 554 5.7.1 <f...@dom-redir.it>: Relay 
> access denied; from=<r...@wp-host1.xyz.com> to=<f...@dom-redir.it> 
> proto=ESMTP helo=<wp-host1.xyz.com>

It this is this an INTERNAL DESTINATION, add it to main.cf:relay_domains.

    relay_domains = dom-redir.it, ...

If this is an EXTERNAL DESTINATION, authorize the client with mynetworks
or with SASL authentication.

    smtpd_recipient_restrictions = 
        permit_mynetworks, permit_sasl_authenticated, ...

        Wietse
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