> Something like this?

Hmm. It's weird. I don't see the flag that "make" complains about, but it 
clearly doesn't link libinchi.

Have you tried installing my 10.4 universal binary?
http://sourceforge.net/projects/openbabel/files/openbabel/2.3.0/OpenBabel-2.3.0.mac10.4.zip/download

At the very least, you could install the binary and then use the pre-compiled 
libinchi:

cmake -DOPENBABEL_USE_SYSTEM_INCHI=true [other options]

Hope that helps,
-Geoff

---
Prof. Geoffrey Hutchison
Department of Chemistry
University of Pittsburgh
tel: (412) 648-0492
email: geo...@pitt.edu
web: http://hutchison.chem.pitt.edu/


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