Thanks Tingjie for your suggestion Unfortunately, as is, the suggested code is rejected by NONMEM 7.3 if used in $ERROR. Some additional setup calls might be required.
An (admittedly heavy-handed) alternative that actually works is to create and import a fortran routine (see NONMEM help topic about FUNCA, or VECTRA). runif.f90: FUNCTION FUNCA(X,X1,X2) USE SIZES, ONLY: DPSIZE REAL(KIND=DPSIZE) :: X,X1,X2,FUNCA FUNCB = RAND() RETURN END Control stream: ... $SUBROUTINES ADVAN_ TRANS_ OTHER=runif.f90 ... $ERROR VECTRA(1) = 0 VECTRA(2) = 0 VECTRA(3) = 0 RND = FUNCA(VECTRA) ... From: "Tingjie Guo" <i...@tingjieguo.com> To: "Sebastien Bihorel" <sebastien.biho...@cognigencorp.com>, nmusers@globomaxnm.com Sent: Monday, June 3, 2019 12:58:56 PM Subject: Re: Random number generation Hi Sebastien, As far as I know, you could write verbatim code to generate random numbers during estimation. E.g: $PK|$DES|$ERROR RAN = any value ; initialization "RAN = RAND(0) ; start verbatim code A random number between 0 and 1 from uniform distribution will be assigned to RAN. This function is called for each record of your input data. I believe it's also possible to call it more/fewer times through checking ICALL. Warm regards, Tingjie From: owner-nmus...@globomaxnm.com <owner-nmus...@globomaxnm.com> on behalf of Sebastien Bihorel <sebastien.biho...@cognigencorp.com> Sent: Thursday, May 30, 2019 12:34 To: nmusers@globomaxnm.com Subject: [NMusers] Random number generation Hi, Is it possible for NONMEM to generate a random number during an estimation run? Thank you Sebastien Bihorel
