Hi all,
I don't think we should do analyze two drugs simultaneously. I DO agree
that two drugs may correlate to each other through physiology.
However I think we should analyze factors in physiology first. Then we
can analyze the correlation between two drug.
Regards,
Masaki
On 2016/09/06 20:34, r.terhe...@radboudumc.nl wrote:
Hi all,
I guess that if both drugs are given to the same person, it makes a
lot of sense to perform simultaneous modeling, because of physiology,
a lot of parameters will show covariance. The PK of one drug can
therefore partially explain the PK of the other one (and vice versa).
Cheers,
Rob
**
*---*
*Dr. R. ter Heine, hospital pharmacist-clinical pharmacologist*
*Head of Clinical Trials Unit, Dept. of Pharmacy*
*Radboudumc *
T +31-24-36 16405
F +31-24-36 68755
*Van:*owner-nmus...@globomaxnm.com
[mailto:owner-nmus...@globomaxnm.com] *Namens *Pavel Belo
*Verzonden:* dinsdag 6 september 2016 3:04
*Aan:* Penland, Chris
*CC:* nmusers@globomaxnm.com
*Onderwerp:* RE: [NMusers] Simultaneous pk model of 2 drugs
Hello Chris,
What is the point of modeling 2 drugs in one NONMEM code? Do the
drugs interact? For example, you can have 2 monoclonal antibodies
competing for or binding to the same target and/or concentration of
one drug changes elimination rate or some other parameters of the
other one. If they do not interact, you can model them separately.
In some cases, even if they interact you can model them separately
using dose of one drug as a covariate for the other one.
Regards,
Pavel
On Fri, Sep 02, 2016 at 01:22 PM, Penland, Chris wrote:
Greetings NMusers,
Does nonmem have the capacity, unbeknownst to me, for modeling two
simultaneous drugs?
I would like some suggestions about how to define the dataset and
model for a subcutaneous drug and oral drug being administered on
different schedules. I would use DVID = 1 and 2 for the two plasma
pk observations. I figure this soft of thing had to be dealt with
in the past when trying to model dynamic DDIs (vs, just taking one
of the drugs as a covariate on the other’s parameters).
One approach is to specify the compartments for each to be dosed
into then have those feed the central, but I’m curious to see if
there is something more subtle in the nonmem syntax. Is there
something about EVID, that I don’t know that would help (beyond
EVID=1 for dosing)
What if you had two oral drugs? Would you treat the two dosing
compartments as separate and possibly link them together at the
parameter/covariance level?
Thanks,
Chris
Chris Penland, PhD
ECD / Quantitative Clinical Pharmacology
Waltham, MA USA
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