Hi Chris, I think that the most straight-forward way to handle this is to have two sets of compartments and write the $DES block manually (or writing the algebraic equations if it's a one- or two-compartment model).
It wouldn't be straight-forward to model if the subjects receive the drugs at the same time. If the drugs are received at separate times (like different periods of a study or even different studies), then the DVID flag idea would work, too. There are only five EVID values as far as I know, and there's not a subtle way to use them for two doses, I don't think: • 0= observation • 1= dose • 2= other (I usually use it to reset the compartment) • 3= reset the subject • 4= reset and dose at the same time Thanks, Bill > On Sep 2, 2016, at 1:22 PM, Penland, Chris <chris.penl...@astrazeneca.com> > wrote: > > Greetings NMusers, > > Does nonmem have the capacity, unbeknownst to me, for modeling two > simultaneous drugs? > > I would like some suggestions about how to define the dataset and model for a > subcutaneous drug and oral drug being administered on different schedules. I > would use DVID = 1 and 2 for the two plasma pk observations. I figure this > soft of thing had to be dealt with in the past when trying to model dynamic > DDIs (vs, just taking one of the drugs as a covariate on the other’s > parameters). > > One approach is to specify the compartments for each to be dosed into then > have those feed the central, but I’m curious to see if there is something > more subtle in the nonmem syntax. Is there something about EVID, that I don’t > know that would help (beyond EVID=1 for dosing) > > What if you had two oral drugs? Would you treat the two dosing compartments > as separate and possibly link them together at the parameter/covariance level? > > Thanks, > Chris > > > Chris Penland, PhD > ECD / Quantitative Clinical Pharmacology > Waltham, MA USA > > > Confidentiality Notice: This message is private and may contain confidential > and proprietary information. If you have received this message in error, > please notify us and remove it from your system and note that you must not > copy, distribute or take any action in reliance on it. Any unauthorized use > or disclosure of the contents of this message is not permitted and may be > unlawful. > > > > > > > >
