Joachim, I found the following also useful in calculating df from IW distribution.
Dansirikul C, Morris RG, Tett SE, Duffull SB. A Bayesian approach for population pharmacokinetic modelling of sirolimus. Br J Clin Pharmacol. 2006 Oct;62(4):420-34. Regards, Ayyappa From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Mats Karlsson Sent: Wednesday, February 22, 2012 9:58 AM To: 'Joachim Grevel'; 'Coen van Hasselt'; 'nmusers' Subject: RE: [NMusers] OMEGA priors using modes of inverse Wishart matrix Dear Joachim, The IW distribution is not something you get from NONMEM, you have to give the degrees of freedom of the IW prior distribution. Normally this is at or below the number of subjects in you previous study depending the information about the parameter per subject. In addition to User's Guides, you may find useful info in Gisleskog et al J Pharmacokinet Pharmacodyn. 2002 Dec;29(5-6):473-505. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 75124 Uppsala Phone: +46 18 4714105 Fax + 46 18 4714003 From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Joachim Grevel Sent: 22 February 2012 15:24 To: 'Coen van Hasselt'; nmusers Subject: RE: [NMusers] OMEGA priors using modes of inverse Wishart matrix Dear Coen, There I do have the answer: with MCMC Bayesian in NONMEM 7.1 you have to use NWPRI according to the guide. Dear Nidal, What I try to do is that: use an existing very well defined popPK model (2500 conc in 200 patients) to obtain individual PK parameters in only 20 additional patients that have sparse sampling (2 to 4 conc per patient). I was planning to use informative priors rather than add 80 conc to a bulk of 2500 conc. What do you think? Thanks to all, specifically Tim! Joachim From: Coen van Hasselt [mailto:coen.vanhass...@slz.nl]<mailto:[mailto:coen.vanhass...@slz.nl]> Sent: 22 February 2012 14:03 To: jgre...@o2.co.uk<mailto:jgre...@o2.co.uk> Subject: Re: [NMusers] OMEGA priors using modes of inverse Wishart matrix Dear Joachim, I have always wondered about this particular question myself as well.. Thanks for asking at NMusers. Another thing related to the PRIORs I was wondering about: you can either use NWPRI (i.e. with the inverse wishart for OMEGA's), or TNPRI, which uses a multivariate normal for the OMEGA's. Do you have any idea when to use either of these two possible implementations ? Thanks, Coen >>> "Joachim Grevel" 02/22/12 2:11 PM >>> Dear NMusers, Our NONMEM User Guides are full of good advice and they are searchable. Yet when I tried to find out whether any of the estimation methods could be enticed to give me the ?inverse Wishart matrix? needed to specify PRIORS for OMEGAs, I found no help. Leonid G. mentions the inverse Wishart matrix in his historic contributions to NMusers, but again I could not find out how to obtain it. If it does not happen in NONMEM, is there a tool in R that can give me that matrix? Your help is greatly appreciated, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited BioCity Nottingham Pennyfoot Street Nottingham, NG1 1GF Tel: +44 (0)115 8120497
